Ghufran, Isewid, (PhD)
Clinical Laboratory Sciences Department, Faculty of Pharmacy, Al-Qadisiyah University-Iraq
Abstract
Background: International scientific recognition has recently been given to the use of phytochemicals to avoid major health problems. Research on pharmacological processes and the search for chemical structures of plant extracts with anticancer activities aroused interest. The Aim of work: This study was to assess the chemotherapeutic anti-tumor ability of Black cohosh extract against mammary carcinogenesis in Swiss albino mice that was generated by the implantation of Ehrlich ascites carcinoma (EAC). Materials and techniques: Black cohosh extracts were evaluated for their effectiveness against EAC by tracking tumor weight, volume, and occurrence. Lipid peroxidation (MDA) and the biochemical oxidative stress-related profile were studied, as were the antioxidants-related profile, which included the activity of superoxide dismutase (SOD), glutathione reductase (GR), glutathione-s-transferase (GST), total antioxidant capacity (TAC), catalase, and CAT, as well as the hepatic and renal toxicity markers (creatinine, urea, and transaminases) and histopathological changes after treatment. The Results: The results showed that oxidative stress was reduced, antioxidant levels were raised, liver and kidney functions were restored, and tumor and neovascularization were inhibited. Conclusion: Based on all obtained data, our research suggests that treatment with Black cohosh extract offered robust antioxidant protection and chemotherapeutic efficacy against mammary tumors implanted with EAC.
Study the Potential Role of Black cohosh Extract on Cancer Treatment